Proposed Framework for MENA-SINO Guidelines adaptation and Practice Parameters development

Abstract

Evidence-based guidelines tailored to the Middle East and North Africa (MENA) region are critical for improving stroke and neurointerventional outcomes, given varied epidemiological profiles, resource disparities, and cultural factors. This manuscript outlines a comprehensive framework established by the Middle East North Africa Stroke and Interventional Neurotherapies Organization (MENA-SINO) to develop, adapt, and update guidelines. The framework incorporates recognized methodologies (e.g., GRADE), encourages multidisciplinary collaboration, and addresses region-specific needs through “Resource-Limited” tags and novel Expert Opinion (EO) processes. “Mini Updates” function as a rapid mechanism to integrate high-impact new evidence into existing guidelines. By embedding robust stakeholder engagement, conflict-of-interest safeguards, and transparent publication procedures, this approach aims to unify practices and enhance the quality of stroke and neurointerventional care across diverse MENA healthcare settings.