Ulcerative Colitis Presenting with Bilateral Thalamic Infarcts Due to Cerebral Sinus Thrombosis

Abstract

A 35-year-old woman with ulcerative colitis was transferred to our hospital because of 2-day history of altered
mental status and headache. Apparently, 2 weeks prior
to the transfer she had been having increased nausea,
vomiting, and diarrhea. She was diagnosed and reported
with extensive thrombosis of the intracranial venous
system. There was thrombosis of internal cerebral veins,
the superior sagittal sinus, straight sinus, and transverse
and sigmoid sinuses with extension into jugular veins.
There was also acute ischemia of thalami bilaterally.
Homocysteine and protein C levels were normal. Protein
S and thrombin levels were slightly low. Subsequently,anticoagulation was initiated with continuous intravenous infusion of heparin.