Stroke Mimic Secondary to IV Fentanyl Administration

Abstract

Fentanyl is a potent opioid used commonly in acute care because of its rapid onset and short duration of
action. It has fewer side effects when compared with commonly available opioids, such as morphine and
hydromorphine. We report an unusual side effect of transient aphasia following fentanyl administration. A
61-year-old female presented for an elective embolization of a periophthalmic artery aneurysm. She developed immediate episodes of aphasia on two separate occasions following administration of intravenous
(IV) fentanyl. The high lipid solubility explains the rapid onset of action of fentanyl as it rapidly passes
through the blood–brain barrier and through cell membranes. Immediately following the administration of
fentanyl, the patient developed aphasia. There were no other clinical or neurological imaging findings that
could account for these symptoms. We believe that aphasia may be an unusual side effect of fentanyl, and it
is something clinicians should be aware of.