Trophic Factors and Stem Cells for Promoting Recovery in Stroke

Abstract

Background: Stem cell therapy for stroke is in its initial stages as an option to restore lost neurological functions after stroke.
Objective: To provide a comprehensive review of studies involving stem cells in stroke
treatment and to highlight new evidence from the ongoing clinical trials.
Methodology:We performed a systematic study of various published journals in online medical
libraries using Pubmed, Sciencedirect, and hajournal. Evidence synthesis is done with
specific search words of – stem cell therapy, stroke, trophic factor, neural progenitor cell,
pathophysiology, mechanism of action, clinical trial and mesenchymal stem cell in various
combinations. Emphasis was given to articles published in year 2000 and onwards.
Results: Current research on stem cell therapy for stroke focuses on transplantation and
endogenous neurogenesis of stem cells in brain. The sub-ventricular zone in the adult brain is
identified as an endogenous resource of neuronal precursors that can be recruited to adjacent
lesioned areas. Several factors can increase adult neurogenesis by stimulating formation or
improving survival of new neurons, such as FGF-2, EGF, stem cell factor, erythropoietin,
BDNF, caspase inhibitors, and anti-inflammatory drugs. Much of the beneficial effects of
stem cell in stroke models are related to secretion of trophic factors.
Conclusion: The complex pathophysiology involving various trophic factors, growth factor and gene modification in animal studies
have showed promising result. Future research involving these trophic factors should open up new additional or clinically significant
alternative for the treatment of stroke.