Investigation of Gender Differences and Exclusive Criteria in a Diabetic Acute Ischemic Stroke Population Treated with Recombinant Tissue-Type Plasminogen Activator (rtPA)
Creators
Description
Background
Many studies have reported that women who survive stroke have less favorable outcomes than men in the use of rtPA, while others reported worse outcomes in men than women. The gender difference in the exclusion criteria in a diabetic stroke population is not fully understood. This issue was investigated in this study.
Method
In a diabetic stroke population from a stroke registry of data collected between January 2010 to June 30, 2016, the gender difference was determined using demographics and clinical factors. Comparison was determined using univariate analysis while multivariable model was used to adjust for the effect of confounding variables.
Results
In a diabetic stroke population of 439 patients, more females were excluded than males (P < 0.0001, OR = 2.323). The male exclusion was associated with atrial fibrillation (P = 0.011, OR = 3.697), carotid artery stenosis (P = 0.023, OR = 5.001), and cholesterol reducer (P = 0.037, OR = 0.409). In the female diabetic stroke population, exclusion from rtPA therapy was associated with language disturbances (P = 0.039, OR = 0.372), history of previous stroke (P = 0.005, OR = 3.276), antihypertensive medication use (P = 0.013, OR = 0.163), and antidiabetic medication use (P = 0.031, OR = 0.324).
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